5 Immunotoxicity
نویسندگان
چکیده
As evidenced by recent documents prepared by the Office of Technology Assessment (9) and the National Research Council in 1992 (8) focusing on immunotoxicology, there has been growing interest and concern within the scientific and public communities on the capacity of environmental agents to perturb normal immune processes. The types of effects that may occur are often agent-specific as well as species-specific and include immuno-suppression in which either systemic or local immunity is targeted (e.g., lung or skin), hypersensitivity disease, manifested as respiratory tract allergies or contact allergic dermatitis, and in certain instances autoimmunity or increased autoantibodies without evidence of disease. In addition to environmental pollutants, other agents of concern have included certain therapeutics, consumer products and biological (e.g., the therapeutic use of recombinant materials). More recently, interest has also focused on potential immunological effects by such diverse agents as excessive UV-B light, electromagnetic fields and pollutants found in the indoor environment. Common indoor pollutants can include not only chemical agents but also bioaerosols such as viruses, bacteria, fungi, algae and protozoa which have the potential to act as either sensitizing agents or mediators of infectious disease.
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